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KMID : 1235520110100010026
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Research in Vestibular Science
2011 Volume.10 No. 1 p.26 ~ p.29
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C-fos Expression of Vestibular Nucleus in C57BL/6 Mouse Under the 7 Tesla Ultra High Magnetic Field
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Kim Mi-Joo
Jung Min-Joo
Bae Ji-Hye
Lee Eun-Ji
Kim Duk-Hyun
Han Gyu-Cheol
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Abstract
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Background and Objectives: A typical side effect of super high magnetic field is dizziness and it is expected that 7 Tesla (T) super high magnetic field will have temporary influence on vestibular nucleus. Prevalence rate of dizziness generally increases with advancing years, so this study discusses whether the influence of 7 T super high magnetic field differs depending on the age.
Materials and Methods: C57BL/6 mice weighting from 10-40 g were categorized into 4-week-old and 16-week-old groups. They were exposed to 7 T magnetic field and immunohistochemical staining was done to observe expression of c-fos protein in vestibular nucleus of mice.
Results: Control group with normal vestibular system did not show c-fos protein. However, mice exposed to 7 T magnetic field showed c-fos expression selectively on medial and lateral parts of vestibular nucleus and there was no significant difference of c-fos expression between both sides (p<0.05). There was statistically significant difference between the different age group: 16-week-old mice group showed higher number of cells expressing c-fos protein than 4-week-old mice group did (p<0.05).
Conclusion: It is statistically significant that 7 T super high magnetic field is more influential to older age group.
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KEYWORD
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7 Tesla, Magnetic resonance imaging, c-fos, Vestibular neucleus, Aging
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